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Cloned rat M3 muscarinic receptors mediate phosphoinositide hydrolysis but not adenylate cyclase inhibition
Author(s) -
Pinkas-Kramarski Ronit,
Stein Reuven,
Zimmer Yitzhak,
Sokolovsky Mordechai
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)80911-6
Subject(s) - adenylate kinase , cyclase , muscarinic acetylcholine receptor , receptor , muscarinic acetylcholine receptor m5 , chemistry , cloning (programming) , biochemistry , biology , microbiology and biotechnology , muscarinic acetylcholine receptor m3 , computer science , programming language
Rat M3 mAChR subtype was stably expressed in RAT 1 cells. Investigation of the pharmacological and biochemical properties of the cloned M3 receptors revealed that they mediate phosphoinositide hydrolysis but not adenylate cyclase inhibition. The similarities and differences between the properties of cloned rat M1 and M3 receptors are discussed.