Premium
Membrane action of synthetic N‐terminal peptides of influenza virus hemagglutinin and its mutants
Author(s) -
Düzgüneş Nejat,
Gambale Franco
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)80879-2
Subject(s) - hemagglutinin (influenza) , lipid bilayer fusion , mutant , liposome , membrane , virus , influenza a virus , lipid bilayer , orthomyxoviridae , chemistry , phospholipid , biology , biophysics , virology , biochemistry , gene
Synthetic peptides corresponding to the N‐terminal of the cleaved hemagglutinin (HA2) of influenza virus induce an increase in conductance of planar phospholipid bilayers, and cause the release of encapsulated molecules from large unilamellar liposomes. Two mutant peptides, derived from hemagglutinins of mutant viruses with no or reduced fusion activity, do not alter the membrane conductance significantly. These observations support the hypothesis that influenza virus fuses with its target membrane by inserting the HA2 N‐terminal into the membrane.