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Cloning and sequence analysis of cDNA encoding the precursor of a human endothelium‐derived vasoconstrictor peptide, endothelin: Identity of human and porcine endothelin
Author(s) -
Itoh Yasuaki,
Yanagisawa Masashi,
Ohkubo Shoichi,
Kimura Chiharu,
Kosaka Takuo,
Inoue Akihiro,
Ishida Norio,
Mitsui Youji,
Onda Haruo,
Fujino Masahiko,
Masaki Tomoh
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)80867-6
Subject(s) - complementary dna , endothelin receptor , peptide sequence , endothelins , microbiology and biotechnology , biology , nucleic acid sequence , cdna library , molecular cloning , peptide , endothelin 1 , biochemistry , gene , receptor
A cDNA encoding a human endothelium‐derived vasoconstrictor peptide, endothelin, was isolated from a human placenta cDNA library. The nucleotide sequence of this cDNA clone showed that the primary structure of the human preproendothelin has 212 amino acid residues and is highly homologous to porcine preproendothelin, and that human endothelin is identical with porcine endothelin.