Premium
Biological properties of dihydro‐leukotriene B 4 , an alternative leukotriene B 4 metabolite
Author(s) -
Kaever V.,
Damerau B.,
Wessel K.,
Resch K.
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)80855-x
Subject(s) - metabolite , leukotriene , chemistry , biology , biochemistry , immunology , asthma
Dihydro‐leukotriene B 4 (a 5,12‐dihydroxy‐eicosatrienoic acid) has been shown to be the primary metabolite of leukotriene B 4 , (LTB 4 ) in a variety of cells other than human polymorphonuclear leukocytes (PMNLs). In this report we show that dihydro‐LTB 4 is significantly less active than LTB 4 in different biological assay systems, i.e. leukocyte chemotaxis, chemokinesis, aggregation, adhesion to endothelium and superoxide anion production. This suggests that primary reduction constitutes a second so far unknown deactivation pathway for LTB 4 .