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Heparin inhibits IP 3 ‐induced Ca 2+ release in permeabilized pancreatic β‐cells
Author(s) -
Nilsson Thomas,
Zwiller Jean,
Boynton Alton L.,
Berggren Per-Olof
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)80829-9
Subject(s) - heparin , chemistry , biophysics , pharmacology , biochemistry , medicine , biology
Heparin was found to inhibit the Ca 2+ release induced by inositol 1,4,5‐trisphosphate (IP 3 ) in permeabilized pancreatic β‐cells obtained from obese hyperglycemic mice. The effect of heparin was dose‐dependent and not due to inhibition of Ca 2+ uptake into the IP 3 ‐sensitive pool. The effect appeared specific for heparin and was not reproduced by other polysaccharides such as chondroitin sulfates. Heparin might consequently be a useful tool when investigating the molecular mechanism whereby IP 3 mobilizes Ca 2+ .