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Developmentally regulated alternative splicing of brain myelin‐associated glycoprotein mRNA is lacking in the quaking mouse
Author(s) -
Fujita Nobuya,
Sato Shuzo,
Kurihara Tadashi,
Inuzuka Takashi,
Takahashi Yasuo,
Miyatake Tadashi
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)80762-2
Subject(s) - exon , myelin associated glycoprotein , rna splicing , alternative splicing , messenger rna , myelin , biology , glycoprotein , nucleotide , microbiology and biotechnology , gene , rna , genetics , central nervous system , neuroscience
Evidence is presented that expression of the two myelin‐associated glycoprotein mRNAs is developmentally regulated in mouse brain. In quaking mouse, the mRNA without a 45‐nucleotide exon portion was scarcely expressed throughout development. We conclude that the mechanism of splicing out the 45‐nucleotide exon portion is lacking in quaking mouse.