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Diol lipids are activators of protein kinase C
Author(s) -
Severin Sergey E.,
Tovmasyan Eranui K.,
Shvets Vitaly I.,
Molotkovsky Julian G.,
Bergelson Lev D.
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)80754-3
Subject(s) - phosphatidylserine , phosphatidylinositol , diol , biochemistry , chemistry , protein kinase a , kinase , protein kinase c , phospholipid , membrane , organic chemistry
Diol lipids (dioleoyl‐ and dioctanoylethylene glycol) at relatively low concentrations (∼ 10 μM) were found to activate significantly protein kinase C in the presence of phosphatidylserine or phosphatidylinositol. Since diol lipids are widespread minor lipid constituents of many cells [(1974) Chem. Ind., 597–604], it has been suggested that they may be involved in the maintaining of basal protein kinase C activity in the absence of external stimuli.