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Epidermal plasminogen activator inhibitor (PAI) is immunologically identical to placental‐type PAI‐2
Author(s) -
Hibino T.,
Izaki S.,
Ohkuma M.,
Kon S.,
Thorsen S.,
Åstedt B.
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)80731-2
Subject(s) - plasminogen activator , epidermis (zoology) , immunohistochemistry , microbiology and biotechnology , plasminogen activator inhibitor 1 , chemistry , biology , endocrinology , immunology , anatomy
Plasminogen activator inhibitor (PAI) purified from human epidermis [(1986) FEBS Lett. 408, 273–277] was immunologically identified as placental‐type PAI‐2. In both fibrinolytic and synthetic substrate assays inhibitory activity of epidermal PAI was neutralized by anti‐PAI‐2, but not by anti‐endothelial type PAI‐1. Immunoblotting technique confirmed that the purified epidermal PAI is reactive with anti‐PAI‐2, but not with anti‐PAI‐1. Consequently PAI in human epidermis was demonstrable by immunohistochemical technique.