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Human ubiquitin genes: One member of the UbB gene subfamily is a tetrameric non‐processed pseudogene
Author(s) -
Cowland Jack B.,
Wiborg Ove,
Vuust Jens
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)80728-2
Subject(s) - pseudogene , subfamily , gene , genetics , biology , gene family , coding region , microbiology and biotechnology , gene expression , genome
The human ubiquitin gene family consists of three subfamilies. One of these, the UbB subfamily, includes a functional gene coding for a polyubiquitin protein that contains three ubiquitin copies tandemly repeated, as well as three pseudogenes of the processed type. We have now isolated a fifth human UbB type gene, different from any of the previously identified ones. This newly isolated gene is a tetrameric pseudogene which has presumably arisen by unequal crossing‐over of two ancestral trimeric alleles. Southern blotting data indicate that all members of the human UbB gene subfamily are now accounted for.