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Evidence that muscarinic potentiation of insulin release is initiated by an early transient calcium entry
Author(s) -
Sánchez-Andrés J.V.,
Ripoll Cristina,
Soria Bernat
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)80719-1
Subject(s) - long term potentiation , muscarinic acetylcholine receptor , calcium , transient (computer programming) , insulin , medicine , endocrinology , chemistry , computer science , receptor , operating system
The increased insulin release induced by carbamoylcholine (CbCh) in pancreatic islets requires the presence of extracellular Ca 2+ . Intracellular recordings demonstrate that CbCh produces a transient increase in Ca 2+ channel activity lasting from 30 to 60 s. Thereafter activity decreased to levels lower than in controls. When extracellular Ca 2+ was present during this initial period, the stimulatory effects of CbCh were not different from those in which Ca 2+ was present throughout. These experiments suggest that during muscarinic potentiation of insulin release extracellular calcium is only needed in the first minute.