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Autoantibodies to the core proteins of hnRNPs
Author(s) -
Dangli Amalia,
Guialis Apostolia,
Vretou Evangelia,
Sekeris Constantine E.
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)80714-2
Subject(s) - autoantibody , antibody , antigen , core (optical fiber) , hela , systemic lupus erythematosus , chemistry , microbiology and biotechnology , immunology , medicine , virology , biology , pathology , biochemistry , cell , materials science , disease , composite material
A novel autoantibody reacting with the core polypeptides of hnRNP particles has been detected in the serum of a patient with systemic lupus eythematosus (SLE) and Sjögren's syndrome manifestations. Immunoblot analysis, using either rat liver or HeLa nuclear extracts as the antigen source, demonstrated that the autoantibody interacts with a specific subgroup of the core polypeptides of hnRNP particles, namely A 2 , B 1 and B 2 , but not with A 1 , C 1 and C 2 .