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Secretion of a new growth factor, smooth muscle cell derived growth factor, distinct from platelet derived growth factor by cultured rabbit aortic smooth muscle cells
Author(s) -
Morisaki Nobuhiro,
Kanzaki Tetsuto,
Koshikawa Tomoko,
Saito Yasushi,
Yoshida Sho
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)80668-9
Subject(s) - autocrine signalling , platelet derived growth factor receptor , growth factor , platelet derived growth factor , secretion , cell growth , smooth muscle , transforming growth factor , cell , microbiology and biotechnology , endocrinology , vascular smooth muscle , mesenchymal stem cell , platelet , medicine , biology , chemistry , cell culture , immunology , biochemistry , receptor , genetics
In attempts to determine the mechanism of proliferation of arterial smooth muscle cells (SMC) in intimal atheromatous lesions, autocrine secretion of growth factors by SMC has recently received much attention. Here we report a new growth factor named smooth muscle cell derived growth factor (SDGF). Cultured rabbit medial SMC secreted SDGF for 1 week during their incubation in serum‐free media only after at least 4 passages. SDGF differed from platelet derived growth factor (PDGF) physicochemically, immunologically, and biologically. The properties of SDGF also seemed different from those of other known growth factors that stimulate the proliferation of mesenchymal cells.