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Muscarinic receptor‐mediated intracellular Ca 2+ mobilization in embryonic chick heart cells
Author(s) -
Schmidt Heinrich,
Oettling Günter,
Drews Ulrich
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)80636-7
Subject(s) - muscarinic acetylcholine receptor , intracellular , extracellular , muscarinic acetylcholine receptor m1 , stimulation , mobilization , receptor , chemistry , microbiology and biotechnology , biophysics , endocrinology , medicine , biology , biochemistry , history , archaeology
Activation of muscarinic receptors of heart cells elevates the intracellular Ca 2+ concentration. The increase is considered to be due to influx of extracellular Ca 2+ . We show that intracellular Ca 2+ mobilization is involved. Cell suspensions prepared from hearts of 6‐day‐old chick embryos were loaded with the fluorescent Ca 2+ chelator chlortetracycline. Muscarinic stimulation induces a dose‐dependent fluorescence decrease (ED 50 =2.6 × 10 −6 M) indicating intracellular Ca 2+ mobilization.