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Phospholipid peroxidation as a factor in gallstone pathogenesis
Author(s) -
Lichtenberg D.,
Ragimova S.,
Peled Y.,
Halpern Z.
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)80612-4
Subject(s) - lipid peroxidation , phospholipid , cholesterol , chemistry , pathogenesis , phosphatidylcholine , medicine , gallbladder , endocrinology , biochemistry , liposome , biology , antioxidant , membrane
Phospholipid peroxidation markedly reduces the stability of mixed micellar systems composed of cholate, phosphatidylcholine and supersaturating levels of cholesterol. This suggests that lipid peroxidation is likely to play a significant role in the precipitation of cholesterol from gallbladder bile, thus in the pathogenesis of cholesterol gallstones. This conclusion is supported by studies of the nucleation time of cholesterol in gallbladder biles, which was significantly reduced by exposure to a stream of oxygen. This effect of phospholipid peroxidation on cholesterol solubility may occur in other biological fluids as well. In view of the increased lipid peroxidation in the elderly, it may explain the effect of age on the frequency of various diseases related to cholesterol precipitation.