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Heparin inhibits the inositol 1,4,5‐trisphosphate‐induced Ca 2+ release from rat liver microsomes
Author(s) -
Cullen Peter J.,
Comerford John G.,
Dawson Alan P.
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)80584-2
Subject(s) - inositol , chemistry , heparin , microsome , biochemistry , endocrinology , medicine , biology , receptor , in vitro
Inositol 1,4,5‐trisphosphate (Ins (1,4,5)P 3 )‐stimulated Ca 2+ release is inhibited by low concentrations of heparin (IC 50 =4.5 μg/ml). GTP‐stimulated Ca 2+ release is unaffected at a heparin concentration of 16 μ/ml. Addition of heparin after Ins (1,4,5)P 3 causes the rapid re‐uptake of Ins (1,4,5)P 3 ‐releasable Ca 2+ .