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Growth hormone‐albumin conjugates Reduced renal toxicity and altered plasma clearance
Author(s) -
Poznansky Mark J.,
Halford Jennifer,
Taylor Donna
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)80537-4
Subject(s) - nephrotoxicity , albumin , pharmacokinetics , growth hormone , toxicity , chemistry , hormone , conjugate , endocrinology , medicine , serum albumin , peptide , peptide hormone , pharmacology , biochemistry , biology , mathematical analysis , mathematics
The effective therapeutic use of many small peptides such as growth hormone has been limited by their small molecular masses and rapid clearance by the kidneys. Moreover, various degrees of nephrotoxicity have been reported for small proteins which are readily filtered at the level of the glomerulus. We have attempted to circumvent this drawback by conjugating growth hormone (somatotropin) to serum albumin in an effort to alter the peptide's pharmacokinetics while retaining its biological activity.