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Tissue‐specific expression of mRNAs encoding α‐ and β‐catalytic subunits of protein phosphatase 2A
Author(s) -
Khew-Goodall Yeesim,
Hemmings Brian A.
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)80493-9
Subject(s) - phosphatase , messenger rna , microbiology and biotechnology , protein subunit , protein phosphatase 2 , biology , alpha (finance) , beta (programming language) , alkaline phosphatase , isozyme , g alpha subunit , chemistry , biochemistry , enzyme , gene , medicine , construct validity , programming language , nursing , computer science , patient satisfaction
The mRNAs encoding the catalytic subunits of the type 1 phosphatase and the α and β forms of phosphatase 2A (termed 2Aα and 2Aβ) were detected in all the porcine tissues examined (brain, heart, muscle, liver, kidney and ovaries). Total phosphatase 2A transcripts were about 10 times more abundant in brain and heart than in the other tissues while the distribution of phosphatase 1 mRNA showed significantly less variation. Phosphatase 2Aα mRNA was about 10 times more abundant than phosphatase 2Aβ mRNA in most tissues. Similarly, both the α and β forms of the mRNA of the catalytic subunit of the phosphatase 2A were present in all the rat tissues examined. In addition to the 2 kb mRNA generally expressed, rat tissues also express a 2.8 kb mRNA related to 2Aα and a 1.3 kb mRNA related to 2Aβ.