Premium
Endothelin stimulates c‐fos and c‐myc expression and proliferation of vascular smooth muscle cells
Author(s) -
Komuro Issei,
Kurihara Hiroki,
Sugiyama Takao,
Takaku Fumimaro,
Yazaki Yoshio
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)80489-7
Subject(s) - vascular smooth muscle , endothelin 1 , chemistry , smooth muscle , microbiology and biotechnology , c fos , endothelin receptor , cell growth , endocrinology , medicine , gene expression , biology , receptor , biochemistry , gene
Recently, a potent vasoconstrictor peptide, endothelin (EDT), was isolated from vascular endothelial cells. We examined its effect on rat vascular smooth muscle cells (VSMCs). EDT induced the elevation of intracellular calcium, which was dependent on extracellular calcium and inhibited by a calcium‐channel antagonist in a competitive manner. EDT caused a rapid and transient increase in the c‐fos and c‐myc mRNA levels and stimulated the DNA synthesis of VSMCs in a dose‐dependent manner. This effect of EDT on the proliferation of VSMCs might be related to the development of atherosclerosis.