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Degradation of epidermal growth factor receptors by cathepsin L‐like protease: Inhibition of the degradation by c‐Ha‐ ras gene products
Author(s) -
Hiwasa Takaki,
Sakiyama Shigeru,
Yokoyama Shigeyuki,
Ha Jong-Myung,
Noguchi Shigeru,
Bando Yoshiaki,
Kominami Eiki,
Katunuma Nobuhiko
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)80462-9
Subject(s) - cathepsin d , protease , cathepsin , cathepsin o , cathepsin l , epidermal growth factor , cathepsin h , cathepsin b , cathepsin s , receptor , cathepsin l1 , microbiology and biotechnology , cathepsin e , cathepsin c , biology , biochemistry , cathepsin a , chemistry , proteases , enzyme
Extract of N1H3T3 mouse fibroblasts contains a protease which can cleave epidermal growth factor receptor (EGF receptor). This protease was tentatively named cathepsin X and purified to near homogeneity. The characteristics of cathepsin X were similar to those of cathepsin L and the proteolytic activity of cathepsin X was inhibited by c‐Ha‐ ras gene products.