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Organization of 5′proximal c‐myb exons in chicken DNA Implications for c‐myb tissue‐specific transcription
Author(s) -
Soret Johann,
Vellard Michel,
Martinerie Cécile,
Perbal Bernard
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)80422-8
Subject(s) - myb , biology , complementary dna , exon , microbiology and biotechnology , transcription (linguistics) , genomic dna , genomic organization , dna , gene , transcription factor , genetics , genome , linguistics , philosophy
The organization of 5′‐proximal c‐myb exons in chicken DNA has been established by restriction enzyme mapping and nucleotide sequencing. Hybridization studies performed with cDNA probes revealed that yolk sac and thymic c‐myb RNAs differ in their 5′‐termini. A comparison of the genomic c‐myb sequence with that of cDNAs isolated from normal thymic and lymphoma avian cells suggests that different promoter regions are used to initiate c‐myb transcription in hematopoietic cells of different origins.