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Nucleotide sequence of the androgen‐dependent arginine esterase mRNA of canine prostate
Author(s) -
Chapdelaine Pierre,
Ho-Kim My-Anh,
Tremblay Roland R.,
Dubé Jean Y.
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)80414-9
Subject(s) - complementary dna , microbiology and biotechnology , nucleic acid sequence , biology , peptide sequence , messenger rna , coding region , amino acid , biochemistry , gene
The nucleotide sequence of canine prostate arginine esterase mRNA was determined using a 400 bp cDNA clone and primer‐extended cDNA transcripts for the 5′‐coding and noncoding regions. The mRNA contains 864 nucleotides encoding a protein of 236 amino acids preceded by 24 amino acids which constitutes both the signal and the zymogen peptides. The sequence indicates the presence of one potential glycosylation site. A high degree of homology was found between the canine enzyme and other members of the kallikrein family including human prostate specific antigen. The protein appears to be specified by a single gene.