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Humoral mediator‐dependent activation of the Sarcophaga lectin gene
Author(s) -
Shiraishi Akihiro,
Natori Shunji
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)80409-5
Subject(s) - mediator , lectin , chemistry , cd69 , ficolin , c type lectin , lectin pathway , microbiology and biotechnology , biochemistry , mannan binding lectin , biology , immunology , antibody , complement system , in vitro , cytotoxic t cell , alternative complement pathway , il 2 receptor
Sarcophaga lectin is a defence protein synthesized by the fat body and secreted into the hemolymph in response to injury of the body of third instar larvae of Sarcophaga peregrina (flesh‐fly). In this paper, we demonstrate that the stimulus of body injury is first transmitted to a certain tissue present in the anterior part of the body, and from there a mediator molecule that interacts directly with fat body cells is secreted into the hemolymph. On interaction with this mediator molecule, the fat body begins to synthesize mRNA for Sarcophaga lectin.