Premium
Intramitochondrial factors controlling hepatic fatty acid oxidation at weaning in the rat
Author(s) -
Decaux Jean-François,
Robin Danielle,
Robin Pierre,
Ferré Pascal,
Girard Jean
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)80407-1
Subject(s) - ketone bodies , palmitoylcarnitine , beta oxidation , weaning , carnitine , carnitine o palmitoyltransferase , citrate synthase , chemistry , endocrinology , medicine , mitochondrion , biochemistry , acetyl coa , fatty acid , fatty acid synthase , metabolism , biology , enzyme
Fatty acid oxidation was studied in isolated liver mitochondria of rats during the suckling‐weaning transition. The oxidation rate of oleyl‐CoA and palmitoylcarnitine was reduced 2.5‐fold in rats weaned on a high‐carbohydrate diet compared to suckling rats, when acetyl‐CoA produced by β‐oxidation was directed towards ketone‐body synthesis. Weaning on a high‐fat diet minimized this change. Channeling of acetyl‐CoA towards citrate synthesis doubled the oxidation rate of both substrates in HC‐weaned rats. Thus, in addition to changes in carnitine palmitoyltransferase I activity, the β‐hydroxymethylglutaryl‐CoA synthase pathway is also involved in the decreased fatty acid oxidation at weaning. This was confirmed by measurement of β‐hydroxymethylglutaryl‐CoA synthase pathway activity.