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Human orbital tissue and thyroid membranes express a 64 kDa protein which is recognized by autoantibodies in the serum of patients with thyroid‐associated ophthalmopathy
Author(s) -
Salvi M.,
Miller A.,
Wall J.R.
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)80402-2
Subject(s) - thyroid , autoantibody , antigen , antibody , anti thyroid autoantibodies , connective tissue , eye proteins , medicine , eye disease , membrane protein , blot , pathology , endocrinology , microbiology and biotechnology , immunology , biology , membrane , biochemistry , retinal , ophthalmology , gene
A 64 kDa protein has been identified in the membrane fraction of human eye muscle, orbital connective tissue and thyroid, by testing sera of patients with thyroid‐associated ophthalmopathy in SDS‐polyacrylamide gel electrophoresis and Western blotting. Antibodies to this membrane antigen seem characteristic of the early stage of ophthalmopathy. In the thyroid this newly recognized protein seems different from previously known membrane antigens. A thyroid antibody reactive with a 64 kDa membrane antigen in eye muscle could explain the very frequent association of ophthalmopathy with autoimmune thyroid disease.