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VLDL apoprotein secretion and apo‐B mRNA level in primary culture of cholesterol‐loaded rabbit hepatocytes
Author(s) -
Kosykh V.A.,
Surguchov A.P.,
Podres E.A.,
Novikov D.K.,
Sudarickov A.B.,
Berestetskaya Yu.V.,
Repin V.S.,
Smirnov V.N.
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)80395-8
Subject(s) - very low density lipoprotein , apolipoprotein b , secretion , incubation , messenger rna , endocrinology , cholesterol , medicine , chemistry , apolipoprotein e , hepatocyte , biochemistry , lipoprotein , biology , in vitro , gene , disease
Incubation of cultured rabbit hepatocytes with β very low density lipoproteins (β‐VLDL) induces a dose‐dependent increase in cell cholesterol (CH) content and VLDL apoprotein (apo) B and E secretion without change in apo‐B mRNA level. These data suggest that β‐VLDL may exert a stimulatory effect on hepatic apo‐B production at the co‐translational and/or posttranslational level.