Premium
Mesenteric vascular responses to i.v. administration of lipoxin A 4 and lipoxin B 4 in the conscious rat
Author(s) -
Feuerstein Giora,
Siren Anna-Leena
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)80384-3
Subject(s) - lipoxin , medicine , lipoxygenase , hemodynamics , blood flow , blood pressure , pharmacology , endocrinology , chemistry , receptor , biochemistry , enzyme
Lipoxin A 4 and lipoxin B 4 are newly discovered lipoxygenase‐interacting products of leukocytes which might have a role in cardiovascular events associated with anaphylaxis. We have tested this possibility by systemic administration of both LXA 4 and LXB 4 to the conscious rat while monitoring systemic and regional hemodynamic changes. LXA 4 and LXB 4 (1–100 μg/kg) produced dose‐dependent constriction of the mesenteric vessels, up to + 123 ± 23% and + 50 ± 9% for LXA 4 /B 4 , respectively. Dose‐related changes were not observed in arterial blood pressure, heart rate, renal (LXB 4 ) and hindquarter blood flow. We suggest that LXA 4 and LXB 4 might affect selective vascular beds, such as the mesenteric vessels, and contribute to variations in blood flow in specific pathophysiological states.