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Different tachykinin receptor subtypes are coupled to the phosphoinositide or cyclic AMP signal transduction pathways in rat submandibular cells
Author(s) -
Laniyonu A.,
Sliwinski-Lis E.,
Fleming N.
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)80365-x
Subject(s) - tachykinin receptor , pertussis toxin , cyclase , adenylate kinase , phospholipase c , chemistry , g protein , receptor , signal transduction , medicine , submandibular gland , endocrinology , cholera toxin , biology , biochemistry , substance p , neuropeptide
Tachykinins of different classes (NK1, NK2, NK3) caused the concentration‐dependent synthesis of IP 3 in rat submandibular acinar cells with the potency rank order of NK1 < NK2 > NK3. Enhancement of IP 3 was not affected by pertussis toxin treatment. The reverse rank order was found in the tachykinin inhibition of isoproterenol‐induced cAMP synthesis and this inhibition was abolished by pertussis toxin, an inactivator of the adenylate cyclase G i regulatory protein. It is suggested that different tachykinin receptor subtypes are preferentially coupled to phospholipase C or adenylate cyclase by separate G regulatory proteins in rat submandibular acinar cells.