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Human heart cytochrome c oxidase subunit VIII Purification and determination of the complete amino acid sequence
Author(s) -
Van Kuilenburg André B.P.,
Muijsers Anton O.,
Demol Hans,
Dekker Henk L.,
Van Beeumen Jozef J.
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)80353-3
Subject(s) - cytochrome c oxidase , protein subunit , biochemistry , chemistry , peptide sequence , oxidase test , sequence (biology) , microbiology and biotechnology , enzyme , biology , gene
Subunit VIII was purified from a preparation of the human heart cytochrome c oxidase and its complete amino acid sequence was determined. The sequence proved to be much more related to that of the bovine liver oxidase subunit VIII than to that found in bovine heart. Our finding of a ‘liver‐type’ subunit VIII in the human heart enzyme suggests that either there are no isoforms of human subunit VIII or the human oxidase does not show the type of tissue specificity that has been reported for the oxidase in other mammals.