Premium
Complementary addressed modification of nucleic acids with the alkylating derivatives of oligothymidylate ethyl phosphotriesters Effect of the phosphotriester fragments' configuration
Author(s) -
Abramova T.V.,
Vlassov V.V.,
Lebedev A.V.,
Ryte A.S.
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)80323-5
Subject(s) - diastereomer , nucleic acid , chemistry , oligonucleotide , enantiomer , reagent , stereochemistry , dna , combinatorial chemistry , biochemistry , organic chemistry
The alkylating derivatives of four individual diastereomers of the oligonucleotide [dTp(Et)] 3 dTpU and two individual diastereomers of oligonucleotide [dTp(Et)dTp] 4 have been synthesized. The reagents with the phosphorus atoms in the enantiomeric p″ configuration are shown to be more efficient in reacting with poly(dA) and with nucleic acids in Krebs‐2 ascites carcinoma cells compared to those with the phosphorus atoms in the p′ configuration.