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Palmitoyl‐CoA inhibits the mitochondrial inner membrane anion‐conducting channel
Author(s) -
Halle-Smith S.C.,
Murray A.G.,
Selwyn M.J.
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)80305-3
Subject(s) - carnitine , chemistry , inner mitochondrial membrane , mitochondrion , thermogenesis , inner membrane , membrane potential , membrane , voltage dependent anion channel , biophysics , biochemistry , biology , bacterial outer membrane , adipose tissue , escherichia coli , gene
Palmitoyl‐CoA is shown here to inhibit the pH‐dependent anion‐conducting channel (IMAC) in the inner membrane of rat liver mitochondria, with half‐maximal inhibition at 2.4 μM. It has little effect on the transport of ribose, thiocyanate and glutamate. Palmitic acid and palmitoyl‐carnitine stimulate the entry of all the above metabolises. CoASH and carnitine have no effect on chloride uniport. Palmitoyl‐CoA and the IMAC may have a role in controlling thermogenesis in liver mitochrondria.