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Rat cardiac hypertrophy Altered sodium‐calcium exchange activity in sarcolemmal vesicles
Author(s) -
Hanf Remy,
Drubaix Isabelle,
Marotte Françoise,
Lelievre Lionel G.
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)80303-x
Subject(s) - calcium , vesicle , cardiac hypertrophy , chemistry , sodium , sarcolemma , sodium calcium exchanger , medicine , biophysics , muscle hypertrophy , microbiology and biotechnology , biochemistry , biology , membrane , organic chemistry
The sodium‐calcium exchange activity has been studied in sarcolemmal vesicles isolated from rat ventricles hypertrophied by pressure overload. 4 weeks after aortic stenosis the degree of hypertrophy varied from 30 to 70%. The Na + ‐dependent 45 Ca 2+ influx and efflux were up to 50% decreased and the sensitivity to Ca 2+ was 13‐fold lower in vesicles from hypertrophied heart as compared to those from normal heart. However, the Na + ,K + ‐ATPase activity, the orientation of the vesicles and the passive Ca 2+ permeability were found to be similar in the two heart groups. These results indicate that the sarcolemmal Na + /Ca 2+ exchange activity could be qualitatively and/or quantitatively changed in hypertrophied rat heart.