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The maximum of the histone acetyltransferase activity precedes DNA‐synthesis in regenerating rat liver
Author(s) -
Weiss Günter,
Puschendorf Bernd
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)80257-6
Subject(s) - histone acetyltransferase , dna synthesis , histone h1 , histone , dna replication , acetylation , histone h2a , dna , microbiology and biotechnology , biology , chemistry , biochemistry , gene
A pronounced transitory increase of histone acetyltransferase (EC 2.3.1.48) activity before the onset of DNA replication is shown to occur in regenerating rat liver. This effect is followed by an increase in the H1/H1° ratio at the start of DNA synthesis; H1° is replaced by H1. Histone acetylation and H1/H1° exchange are discussed as steps in the signal transduction for DNA replication.