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Seminal pepsinogen C is not identical with, but is very similar to gastric pepsinogen C
Author(s) -
Szecsi P.B.,
Koch C.,
Foltmann B.
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)80234-5
Subject(s) - pepsin , chemistry , gastric chief cell , biochemistry , gastric mucosa , stomach , enzyme
Human seminal pepsinogen C has been purified and compared with gastric pepsinogen C. The two zymogens cannot be distinguished by amino acid compositions and sequences of the first 28 N‐terminal amino acid residues are identical. Apparent immunological identity is observed with polyclonal antisera. Monoclonal antibodies toward seminal pepsinogen C have been produced. One is able to recognize a non‐carbohydrate antigenic determinant only present in seminal pepsinogen C.