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Contractile activity enhances the synthesis of hexokinase II in rat skeletal muscle
Author(s) -
Weber F.E.,
Pette D.
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)80227-8
Subject(s) - hexokinase , methionine , gene isoform , stimulation , skeletal muscle , in vivo , tibialis anterior muscle , enzyme , medicine , chemistry , endocrinology , biochemistry , enzyme assay , biology , glycolysis , amino acid , microbiology and biotechnology , gene
An 11‐fold increase in hexokinase activity and the hexokinase II isoform was found in rat tibialis anterior muscle after 7 days of chronic, low‐frequency stimulation. In vivo labeling studies showed that this increase in enzyme protein content was related to an approx. 30‐fold increase in [ 35 S]methionine incorporation.