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N ‐(2‐Hydroxyethyl)phenazinium derivatives of oligonucleotides as effectors of the sequence‐specific modification of nucleic acids with reactive oligonucleotide derivatives
Author(s) -
Kutyavin I.V.,
Podyminogin M.A.,
Bazhina Yu.N.,
Fedorova O.S.,
Knorre D.G.,
Levina A.S.,
Mamayev S.V.,
Zarytova V.F.
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)80220-5
Subject(s) - oligonucleotide , nucleic acid , sequence (biology) , dna , alkylation , chemistry , effector , biochemistry , nucleic acid sequence , combinatorial chemistry , catalysis
It has been found that mono‐ and especially diphenazinium derivatives of oligonucleotides complementary to the DNA sequence adjacent to the target sequence of the addressed alkylation of DNA, significantly enhance the extent and specificity of alkylation with p ‐( N ‐2‐chloroethyl‐ N ‐methylamino)benzylamide derivatives of the addressing oligonucleotides, thus playing the role of effector of the sequence‐specific (complementary addressed) modification.