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Inhibition of HIV replication by amino‐sugar derivatives
Author(s) -
Fleet George W.J.,
Karpas Abraham,
Dwek Raymond A.,
Fellows Linda E.,
Tyms A.S.,
Petursson Sigthor,
Namgoong Sung K.,
Ramsden Nigel G.,
Smith Paul W.,
Son Jong Chan,
Wilson Francis,
Witty David R.,
Jacob Gary S.,
Rademacher Thomas W.
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)80185-6
Subject(s) - castanospermine , enzyme , sugar , chemistry , amino sugar , glycoprotein , biochemistry , human immunodeficiency virus (hiv) , glycoside hydrolase , glucosidases , amino acid , cytotoxic t cell , biology , in vitro , virology
The plant alkaloids castanospermine, dihydroxymethyldihydroxypyrrolidine and deoxynojirimycin have recently been shown to have potential anti‐HIV activity [(1987) Proc. Natl. Acad. Sci. USA 84, 8120–8124; (1987) Nature 330, 74–77; (1987) Lancet i, 1025–1026]. They are thought to act by inhibiting α‐glucosidase I, an enzyme involved in the processing of N ‐linked oligosaccharides on glycoproteins. We report here the relative efficacy of a spectrum of amino‐sugar derivatives as inhibition of HIV cytopathicity. Several α‐glucosidase inhibitors and α‐fucosidase inhibitors were found to be active at concentrations which were non‐cytotoxic.