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The ‘cation‐dependent’ mannose 6‐phosphate receptor binds ligands in the absence of divalent cations
Author(s) -
Junghans Ulrich,
Waheed Abdul,
von Figura Kurt
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)80176-5
Subject(s) - divalent , chemistry , phosphate , receptor , mannose , mannose 6 phosphate , biochemistry , binding site , organic chemistry , growth factor
The requirement of divalent cations for binding of the 46 kDa mannose 6‐phosphate receptors to phosphomannan and pentamannose 6‐phosphate‐substituted bovine serum albumin was examined. Receptors from human liver and human brain bound to both affinity ligands in the absence or presence of divalent cations with similar efficiency. The requirement for divalent cations therefore appears not to be necessary for the binding.