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Human T cell specific proteinase (HuTSP) is encoded by the T cell and natural killer cell specific human Hanukah factor (HuHF) gene
Author(s) -
Fruth Uli,
Eckerskorn Christoph,
Lottspeich Friedrich,
Kramer Michael D.,
Prester Marlot,
Simon Markus M.
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)80168-6
Subject(s) - serine , biology , proteinase 3 , gene , microbiology and biotechnology , complementary dna , peptide sequence , cell , conserved sequence , biochemistry , genetics , enzyme , antibody , autoantibody
HuTSP, a serine proteinase which is specifically associated with activated T lymphocytes, was purified to homogeneity and characterized. N‐terminal amino acid sequencing revealed identity with a sequence predicted from the human Hanukah factor (HF) gene, which was isolated from a human T cell cDNA library. The dimeric structure of HuTSP, together with its extensive sequence homologies with the murine T cell specific proteinase, MTSP‐1, suggests phylogenetic conservation of this serine proteinase family.