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Acidic fibroblast growth factor stimulates opsin levels in retinal photoreceptor cells in vitro
Author(s) -
Hicks David,
Courtois Yves
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)80141-8
Subject(s) - opsin , retinal , fibroblast growth factor , in vitro , microbiology and biotechnology , fibroblast , biology , photoreceptor cell , dermal fibroblast , cell culture , retina , chemistry , biochemistry , rhodopsin , genetics , receptor , neuroscience
It is demonstrated that newborn rat retinal photoreceptor cells can differentiate in monolayer culture, and synthesize de novo photoreceptor‐specific proteins such as opsin. When maintained in serum supplemented medium on a laminin substrate, these cells survive for up to 3 weeks. The addition of acidic fibroblast growth factor stimulates an increase in the levels of opsin of 5–10‐fold control values, and prolongs cell survival by up to 6 days.