Premium
Redox transformations of quinone antitumor drugs in liver microsomes
Author(s) -
Rumyantseva G.V.,
Weiner L.M.
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)80138-8
Subject(s) - chemistry , quinone , adduct , microsome , hydroxyl radical , redox , catalase , reductase , cytochrome , radical , oxygen , medicinal chemistry , photochemistry , oxidative phosphorylation , stereochemistry , enzyme , biochemistry , organic chemistry
The hydroxyl radical has been spin trapped in microsomal and purified NADPH‐cytochrome P‐450 reductase systems in the presence of adriamycin, daunomycin and mitomycin C. The presence of a lag period in quinone‐stimulated spin‐adduct formation is associated with oxygen removal upon its reduction to H 2 O 2 . The hydroxy radical generation has been stimulated by the Fe‐EDTA complex and completely inhibited by catalase. The mechanism of redox transformations of anthracyclines in a microsomal system has been proposed The single electron reduced quinone‐containing anticancer antibiotics play the following roles: (i) they reduce oxygen to H 2 O 2 and (ii) they reduce the ferric ions necessary for H 2 O 2 decomposition with hydroxyl radical formation.