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Selective inhibition of oat glutathione‐ S ‐transferase activity by tetrapyrroles
Author(s) -
Singh Bal Ram,
Shaw Robert W.
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)80120-0
Subject(s) - chlorophyllin , hemin , biliverdin , glutathione , chemistry , bilirubin , biochemistry , biliverdin reductase , enzyme , glutathione s transferase , transferase , heme , heme oxygenase , biology , chlorophyll , organic chemistry , endocrinology
Inhibition of glutathione‐ S ‐transferase activity by various tetrapyrroles (bilirubin, biliverdin, chlorophyllin and hemin) has been studied. Addition of 77 μM bilirubin or biliverdin inhibited glutathione‐ S ‐transferase activity only by 15–19% whereas 77μM chlorophyllin or hemin inhibited the enzyme activity by 83–86%. The data suggest that oat glutathione‐ S ‐transferases can distinguish between open and closed tetrapyrroles. Possible physiological significance of the observed results is discussed.