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DNA cleavage based on high voltage electric pulse
Author(s) -
Tamiya Eiichi,
Nakajima Yoshiko,
Kamioka Hiroyuki,
Suzuki Masayasu,
Karube Isao
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)80116-9
Subject(s) - cleavage (geology) , chemistry , dna , biophysics , photochemistry , materials science , biochemistry , biology , fracture (geology) , composite material
A high voltage electric pulse was applied to DNA cleavage. The DNA cleavage reaction was dependent on the voltage amplitude, pulse number and pulse width. Radical scavengers and ESR data indicated the possibility that active species such as OH radical were strongly related to DNA cleavage.