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Fc receptor‐mediated transcytosis of IgG‐coated liposomes across epithelial barriers
Author(s) -
Patel Harish M.,
Wild Arthur E.
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)80108-x
Subject(s) - transcytosis , liposome , endocytic cycle , endocytosis , clathrin , microbiology and biotechnology , receptor , chemistry , receptor mediated endocytosis , vesicle , biology , biochemistry , membrane
Drug carriers such as liposomes are not readily transported across cellular barriers that constitute epithelia. However, certain epithelia (rabbit yolk sac endoderm and enterocytes of suckling rat gut proximal small intestine) are well known to transcytose maternal IgG by Fc receptor‐mediated endocytic events. We have shown that coating liposomes with appropriate IgG enhances their transport across these epithelia, as measured both by radioactivity indicative of liposomal membrane or entrapped 125 I‐PVP and [ 3 H]inulin, and by the hypoglycemic effect of entrapped insulin. It is suggested that these transported liposomes follow a pathway of transcytosis in clathrin‐coated vesicles, thus escaping lysosomal degradation.