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The duck β‐globin gene cluster contains a single enhancer element
Author(s) -
Kretsovali A.,
Marcaud L.,
Huesca M.,
Scherrer K.
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)80103-0
Subject(s) - enhancer , gene , transfection , biology , microbiology and biotechnology , gene cluster , globin , enhancer trap , regulatory sequence , genetics , regulation of gene expression , gene expression
An erythroid‐specific enhancer was previously identified in the 3′‐flanking region of the β adult gene in chicken and duck, by transfection into AEV transformed chicken erythroblasts. Here we show that the duck enhancer is equally active in erythroid human K562 cells, presenting an embryonic/fetal program of globin gene expression. Furthermore, no other enhancer was found within the 20 kb of DNA including four β‐like globin genes as well as a 1.5 kb upstream and a 3 kb downstream sequence.