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Unusual biochemistry of changes in neuron membrane permeability evoked by cAMP
Author(s) -
Liberman Efim A.,
Minina Svetlana V.,
Myakotina Olga L.,
Mamikonova Tatyana A.,
Tsofina Lilia M.,
Shklovskl-Kordi Nikita E.
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)80074-7
Subject(s) - neuron , glycolysis , oxidative phosphorylation , chemistry , protein kinase a , protein subunit , phosphorylation , membrane permeability , biochemistry , microbiology and biotechnology , permeability (electromagnetism) , mechanism of action , biophysics , membrane potential , membrane , biology , enzyme , neuroscience , in vitro , gene
Influence of different metabolic poisons on cAMP‐evoked neuron membrane permeability is investigated. Drugs preventing cAMP binding with R subunits of protein kinase decrease the cAMP‐evoked current, but the inhibitor of the C subunit, H8, has no effect. The cAMP‐dependent current is increased by uncouplers and decreased by inhibitors of glycolysis and oxidative phosphorylation. The mechanism of cAMP action on neuron permeability is discussed.