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Activation of an S6 kinase from rat astroglial cells by cAMP
Author(s) -
Pierre Michel,
Gavaret Jean-Michel,
Matricon Carole,
Pomerance Martine,
Jacquemin Claude,
Toru-Delbauffe Danièle
Publication year - 1988
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(88)80002-4
Subject(s) - adenylate kinase , protein kinase a , forskolin , cyclase , mitogen activated protein kinase kinase , chemistry , kinase , cyclin dependent kinase 2 , map kinase kinase kinase , ask1 , microbiology and biotechnology , biochemistry , biology , enzyme , receptor
Forskolin and isoproterenol, agonists of adenylate cyclase activity, and dibutyryl cyclic AMP, stimulated an S6 kinase activity in astroglial cells. This activity was insensitive to the thermostable inhibitor of cyclic AMP‐dependent protein kinase and had the same behaviour on a DEAE‐Sephacel column as the mitogen stimulated S6 kinase. These observations support the idea that the cyclic AMP cascade, as well as various growth factors, can activate S6 kinase.