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Pertussis toxin inhibits the angiotensin II and serotonin‐induced rise of free cytoplasmic calcium in cultured smooth muscle cells from rat aorta
Author(s) -
Bruns Christian,
Marmé Dieter
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)81552-1
Subject(s) - pertussis toxin , depolarization , angiotensin ii , cytosol , medicine , serotonin , endocrinology , vascular smooth muscle , intracellular , calcium , angiotensin receptor , chemistry , cytoplasm , receptor , g protein , biology , biochemistry , smooth muscle , enzyme
Angiotensin II, serotonin and K + ‐depolarization cause an increase in free cytoplasmic Ca 2+ in cultured smooth muscle cells. The involvement of a guanine nucleotide‐binding protein has been investigated by using pertussis toxin. When smooth muscle cells were pretreated with pertussis toxin angiotensin II and serotonin‐induced rise of cytosolic Ca 2+ was found to be significantly reduced whereas the Ca 2+ influx mediated by K + ‐depolarization remained unchanged. These results suggest the participation of a guanine nucleotide‐binding protein in the receptor‐mediated rise of intracellular Ca 2+ .