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Adenosine and oxytocin reverse antagonism of cyclic AMP elevating agents to insulin activation of adipocyte pyruvate dehydrogenase
Author(s) -
Wong Ellen H.A.,
Smith Judith A.,
Jarett Leonard
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)81534-x
Subject(s) - endocrinology , medicine , pyruvate dehydrogenase complex , antagonism , adipocyte , pyruvate dehydrogenase kinase , adenosine deaminase , insulin , adenosine , forskolin , oxytocin , chemistry , pyruvate dehydrogenase phosphatase , biology , biochemistry , adipose tissue , enzyme , receptor , stimulation
ACTH, isoprenaline, forskolin, and dibutyryl cyclic AMP prevented insulin from stimulating adipocyte pyruvate dehydrogenase in the presence of adenosine deaminase. Antagonism was reversed by N 6 ‐phenyliso‐propyladenosine as well as oxytocin. The stimulatory effects of insulin, adenosine and oxytocin on adipocyte pyruvate dehydrogenase appear to be through (a) mechanism(s) which is (are) similar or related.