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Complement‐mediated adherence of immune complexes to human erythrocytes
Author(s) -
Schifferli Jurg A.,
Hauptmann Georges,
Paccaud Jean-Pierre
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)81533-8
Subject(s) - c4a , haemolysis , immune system , toxoid , complement system , classical complement pathway , complement (music) , immunology , chemistry , biology , biochemistry , immunization , gene , phenotype , complementation
The classical pathway of complement is required for the adherence of soluble tetanus toxoid (TT)‐human anti‐TT complexes to erythrocytes. Using human C4‐deficient serum we compared the capacity of the two forms of human C4 (C4A and C4B) to mediate this function: C4A was shown to be 1.5‐fold more efficient than C4B. In contrast, haemolysis by C4B was 3.7‐fold more efficient than by C4A. Such large differences suggest that both forms are complementary, and that C4A is preferentially involved in the processing of immune complexes in humans.