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Human immunoglobulin heavy‐chain multigene deletions in healthy individuals
Author(s) -
Lefranc Marie-Paule,
Lefranc Gérard
Publication year - 1987
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(87)81496-5
Subject(s) - biology , genetics , immunoglobulin heavy chain , antibody , gene , heavy chain , immunoglobulin light chain , population , allele frequency , genotype , medicine , environmental health
Extensive multigene deletions have been described in the human immunoglobulin heavy‐chain constant region genes, some of them encompassing perhaps more than 100 kilobases. These deletions have all been observed in healthy individuals although these individuals lacked several immunoglobulin class or subclasses, being either homozygous for one deletion or heterozygous for two different deletions. The high frequency of consanguinity in the Tunisian population accounts for the high frequency of individuals displaying one or the orther of these deletions in a homozygous state.